Cannabinoid Receptor 1
A cannabinoid receptor antagonist, also known simply as a cannabinoid antagonist or as an anticannabinoid, is a type of cannabinoidergic drug that binds to cannabinoid receptors (CBR) and prevents their activation by endocannabinoids. They include antagonists, inverse agonists, and antibodies of CBRs. The discovery of the endocannabinoid system led to the development of CB1 receptor antagonists.
Cannabinoid Receptor 2
Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body; plant cannabinoids (such as Cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and plant cannabinoids are lipophilic, such as fat soluble compounds.
Terpinolene is a common component of sage and rosemary and is found in the oil derived from Monterey cypress. Its largest use in the United States is in soaps and perfumes. It is also a great insect repellent. Terpinolene is known to have a piney aroma with slight herbal and floral nuances. It tends to have a sweet flavor reminiscent of citrus fruits like oranges and lemons.
Terpinolene has been found to be a central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. Further, terpinolene was found to markedly reduce the protein expression of AKT1 in K562 cells and inhibited cell proliferation involved in a variety of human cancers.
All You Need To Know About Terpinolene And Its Uses
Living in this era where the majority of ailments are treated using pharmaceuticals, it is refreshing to find organic elements to be used for therapeutic purposes. One of the most popular items currently available to treat injuries is tea tree oil and its primary compound is an organism known as terpinolene. While terpinolene does not necessarily have an organic origin, it is most commonly found or rather known to be a part of the terpenes within the cannabis leaf. Oddly enough, this woody compound does not act as an anti-inflammatory or analgesic like cannabis; however, it does have various other therapeutic abilities. This article will examine these abilities and discuss how one can use terpinolene as a medicinal organism.
In 2010 research was published indicating how terpinolene was effective as part of an essential oil to act as an anti-bacterial against potent fungi. The oil was a tea tree and the researchers identified the antimicrobial properties to be the most significant factor in the study. Due to the compound’s success acting as an anti-bacterial in this situation, it was seen that the element can be utilized for medicinal purposes to assist in areas where anti-bacterial are required.
2. Anti-Cancer Medication
In 2012 a study founded that the compound terpinolene could be utilized as a therapeutic element treating individuals suffering from mild cancer. The terpinolene was able to down regulate specific cell proteins that would stunt the growth of the cancerous cells in organism. This was particularly beneficial as it proved to maintain the medical condition; however, there is yet to be an overall cure for the different types of cancer.
3. Heart Disease Treatment
By combining terpinolene with the Vitamins A and E was seen to produce was an effective treatment for mild stages of heart disease. A study conducted in 2005 indicated that this combination was highly therapeutic in preventing the condition through a low-density lipoprotein oxidation. This low-density lipoprotein is known as the “bad cholesterol” and has been identified as one of the major contributors to heart disease causing thousands of deaths in America each year.
4. Use As A Sedative
Despite not being used as an analgesic, terpinolene has been identified as holding highly effective sedative properties. In 2013, research noted that the compound terpinolene was beneficial when applied to mice who were suffering from lack of sleep; thus, it is a trial therapy for individuals who are suffering from insomnia or find it difficult to have a restful night.